A splicing variant in EFCAB7 hinders ciliary transport and disrupts cardiac development

A tunable human intestinal organoid system achieves controlled balance between self renewal and differentiation

Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage-Derived Stem Cells

Volumetric compression develops noise-driven single-cell heterogeneity

Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma

Neoadjuvant chemotherapy-induced remodeling of human hormonal receptor-positive breast cancer revealed by single-cell RNA sequencing

Berberine Protects against Hepatocellular Carcinoma Progression by Regulating Intrahepatic T Cell Heterogeneity.Berberine Protects against Hepatocellular Carcinoma Progression by Regulating Intrahepatic T Cell Heterogeneity.

Disruption of tumor- intrinsic PGAM5 increases anti- PD- 1 efficacy through the CCL2 signaling pathway

Interferon-g-stimulated antigen-presenting cancer associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer

TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance

Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5L+ macrophage efferocytosis via NRP2/PROX1 axis

NAT10 regulates tumor progression and immune microenvironment in pancreatic ductal adenocarcinoma via the N4-acetylated LAMB3-mediated FAK/ERK pathway

Single-cell transcriptomic analysis reveals cellular and molecular changes in EGFR-positive lung adenocarcinoma before and after Furmonertinib treatment

Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix

Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer

Single-cell RNA sequencing reveals heterogeneity among AT2 epithelial cells in the lung adenocarcinoma microenvironment

IL-17–producing γδ T cells in the tumor microenvironment promote radioresistance in mice

CD24 is a promising immunotherapeutic target for enhancing efficacy of third-generation EGFR-TKIs on EGFR-mutated lung cancer

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Diallyl Trisulfide Suppresses 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Carcinogenesis via Modulating Keap1-Nrf2 Axis

Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer

An emerging role of microplastics in the etiology of lung ground glass nodules

PPARα agonist ameliorates cholestatic liver injury by regulating hepatic macrophage homeostasis

Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury

Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient

Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes

Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression

Single-cell transcriptional profiling revealed the protective effects of Buddleoside in sepsis-associated acute liver injury

Regulating Astrocytes via Short Fibers for Spinal Cord Repair

Establishment of human minor salivary gland organoids in laminin-GelMA hydrogel from healthy individuals and Sjogren’s disease patients

Multi-omics-informed hydrogel design: modulating IL-6 to reduce endoplasmic reticulum stress in bone regeneration

Macrophage-related immune responses to polyetherketoneketone bone implants: Single-cell transcriptome analysis

Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy

Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapy

Engineered ETS1-Nanoconjugate Restores Immune Homeostasis through Dual Immune-Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Mapping Immune-Inflammatory Niches on Zirconia Bone Implants: Single-Cell Transcriptomic Profiling

Selective oxidative protection leads to tissue topological changes orchestrated by macrophage during ulcerative colitis

Identification of CD38 high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Unraveling the Microenvironment and the Pathogenic Axis of HIF-1𝜶–Visfatin–Fibrosis in Autoimmune Pancreatitis Using a Single-Cell Atlas

Protein Phosphatase 2A Promotes CD8+ T Cell Effector Function through the Augmentation of CD28 Costimulation

Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs

Single-cell transcriptional responses of T cells during microsporidia infection

NLRP3 inflammasome constrains liver regeneration through impairing MerTK- mediated macrophage efferocytosis

Single-cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co-infection

Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets

Myeloid deficiency of Z‐DNA binding protein 1 restricts septic cardiomyopathy via promoting macrophage polarisation towards the M2‐subtype

Sertoli Cell-Derived Extracellular Vesicles Orchestrate Cadmium-Induced Testicular Inflammation and Fibrosis

Single-cell analysis reveals alternations between the aged and young mice prostates

Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy

Single-nucleus transcriptome profiling of skeletal muscle in Diqing Tibetan pigs with distinct body sizes

Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8+ T cell-secreted CCL5

A cell-type–specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1

Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice

Myeloid-Derived CD38 Mediates Age-Related Endometrial Aging Through NAD+ Depletion

Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming

Single-cell technologies: From research to application

Causal associations between COVID-19 and diseases of seven organs: A proteome-wide Mendelian randomization study

High-throughput single-cell sequencing of activated sludge microbiome

Integrated RNA-seq and snRNA-seq analysis identifies PR10 tandem gene cluster governing early defense against Fusarium wilt in sea island cotton

Cuproptosis Signature Would Reveal the Acute-Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Strain-resolved comparison of beef and draft cattle rumen microbiomes using single-microbe genomics

A multi-omics analysis of pancreatitis: bridging familial genetics and disease progression

Design of the biosensor-dependent coupling system stabilizes the high-synthesis phenotype of cell factory

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution

AbDrop-a scalable microfluidics-enabled platform for rapid discovery and functional analysis of plasma cell-derived antibodies

Leveraging two novel droplet－based single－cell RNA Sequencing platforms: a comparative study with 10x genomics

Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing

Toti-N-glycan Recognition Enables Universal Multiplexed Single-Nucleus RNA Sequencing